The title pretty much says it all...
Investing in BTC, ETH, LTC, etc. might carry less risk, but I think the best way to turn a small initial investment into a fortune is by identifying breakout coins before they become mainstream.
The riskiest way to do this obviously through ICOs, but it is also possible to invest in projects that have made some good progress with a solid team behind them, take on a little bit less risk, and someday walk away with a large multiple of your original investment.
I've already shared my biggest holding (Bottos) in a different thread (https://blockchainforums.info/topic/244/bottos)... I also like HPB and IOT. What are some projects that you think have the potential for massive growth?